Cardiomyocyte Regeneration and Differentiation Switch

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Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation.

Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post-natal development. In adult mammals under homeostatic conditions, cardiomyocytes proliferate at an extremely low rate. Because the mechanisms of cardiomyocyte generation provide potential targets for stimulating myocar...

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Cardiomyocyte Regeneration

Circulation. 2017;136:680–686. DOI: 10.1161/CIRCULATIONAHA.117.029343 680 Cell therapy is an exciting option for repairing the injured heart, one that has attracted considerable interest over the past 15 years. Consensus exists that the injection/infusion or tissue-based implantation of various cell types may exert therapeutic effects,1–3 and there is general agreement that additional molecular...

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Cardiomyocyte Regeneration

The heart was initially believed to be a terminally differentiated organ; once the cardiomyocytes died, no recovery could be made to replace the dead cells. However, around a decade ago, the concept of cardiac stem cells (CSCs) in adult hearts was proposed. CSCs differentiate into cardiomyocytes, keeping the heart functioning. Studies have proved the existence of stem cells in the heart. These ...

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Cardiomyocyte Regeneration: A Consensus Statement

Circulation. 2017;136:00–00. DOI: 10.1161/CIRCULATIONAHA.117.029343 August 15, 2017 1 Cell therapy is an exciting option for repairing the injured heart, one that has attracted considerable interest over the past 15 years. Consensus exists that the injection/infusion or tissue-based implantation of various cell types may exert therapeutic effects,1–3 and there is general agreement that addition...

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Cardiomyocyte Regeneration: A Consensus Statement.

Circulation. 2017;136:00–00. DOI: 10.1161/CIRCULATIONAHA.117.029343 August 15, 2017 1 Cell therapy is an exciting option for repairing the injured heart, one that has attracted considerable interest over the past 15 years. Consensus exists that the injection/infusion or tissue-based implantation of various cell types may exert therapeutic effects,1–3 and there is general agreement that addition...

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ژورنال

عنوان ژورنال: Journal of The Society of Japanese Women Scientists

سال: 2013

ISSN: 1349-4449,2186-3776

DOI: 10.5939/sjws.13003